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Carbon Atom Transfer

Team led by Professor Max Hansmann Publishes Latest Findings in Science

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(v.l.) Dr. Patrick Antoni, Prof. Max Hansmann, M.Sc. Julian Holstein, Dr. Qiu Sun, Dr. David Tymann © TU Dortmund
Authors of the publication (from left): Dr. Patrick Antoni, Prof. Max Hansmann, M.Sc. Julian Hauda, Dr. Qiu Sun, Dr. David Tymann. Not pictured: M.Sc. Jan-Niklas Belting and Dr. Richard Goddard.
Professor Max Martin Hansmann from the Department of Chemistry and Chemical Biology and his team have developed a new reagent with which single carbon atoms can be added to organic molecules to create three-dimensional structures. This development is so significant for basic research that it has been published in the prestigious journal Science. The research work was conducted as part of an ERC Starting Grant awarded to Professor Hansmann by the European Research Council (ERC) in 2022.

In organic synthesis, the addition of single carbon atoms is a very challenging task. However, since carbon backbones form the basis of organic matter, the selective addition of single carbon atoms is particularly important. Very few reagents are suitable for this purpose, and those available are often coupled with disadvantages: For example, they are highly unstable, difficult to produce or react very unselectively. Particularly attractive are special reagents that add carbon atoms and at the same time form four new bonds to the neighboring atoms. These four substituents around the carbon atom open up a three-dimensional space that is important for drug synthesis, for example.

Professor Max Hansmann and his team have now succeeded in synthesizing a new reagent that serves not only as a carbon atom source but also immediately forms several bonds to create such three-dimensional carbon backbones. “We are confident that further exploration of the reactivity of such reagents will facilitate new applications in the selective transfer of carbon atoms,” says Professor Hansmann. 

Among the potential areas of application are, for example, drug research, where there is a great demand for new three-dimensional structures. These could then function, for example, as links in complex active substances and improve pharmacokinetics, which determines the onset, duration and intensity of a drug’s effect. In principle, this synthesis approach and the substantially new concept developed by the team can accelerate the production of compounds containing carbon and make it more sustainable.

Prof. Max Hansmann's team has developed a new reagent to add a C atom to a molecule and to build 3D structures.


Read the Article in Science

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