Team led by Professor Max Hansmann Publishes Latest Findings in Science
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In organic synthesis, the addition of single carbon atoms is a very challenging task. However, since carbon backbones form the basis of organic matter, the selective addition of single carbon atoms is particularly important. Very few reagents are suitable for this purpose, and those available are often coupled with disadvantages: For example, they are highly unstable, difficult to produce or react very unselectively. Particularly attractive are special reagents that add carbon atoms and at the same time form four new bonds to the neighboring atoms. These four substituents around the carbon atom open up a three-dimensional space that is important for drug synthesis, for example.
Professor Max Hansmann and his team have now succeeded in synthesizing a new reagent that serves not only as a carbon atom source but also immediately forms several bonds to create such three-dimensional carbon backbones. “We are confident that further exploration of the reactivity of such reagents will facilitate new applications in the selective transfer of carbon atoms,” says Professor Hansmann.
Among the potential areas of application are, for example, drug research, where there is a great demand for new three-dimensional structures. These could then function, for example, as links in complex active substances and improve pharmacokinetics, which determines the onset, duration and intensity of a drug’s effect. In principle, this synthesis approach and the substantially new concept developed by the team can accelerate the production of compounds containing carbon and make it more sustainable.
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