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The German Research Foundation (DFG) has decided on the establishment of Research Training Group (RTG) 2624 “Biostatistical Methods for High-Dimensional Data in Toxicology” at TU Dortmund University. It will fund the group, whose spokesperson is Professor Jörg Rahnenführer from the university’s Faculty of Statistics, from March next year for initially four years. The grant is worth € 4.5 million.
Within the RTG, statisticians from TU Dortmund University and a colleague from Heinrich Heine University Düsseldorf will supervise doctoral students in cooperation with toxicologists from the Leibniz Research Center for Working Environment and Human Factors (IfADo) at TU Dortmund University and the Leibniz Research Institute for Environmental Medicine (IUF) in Düsseldorf. The funding from the German Research Foundation will be used to finance one postdoctoral and ten doctoral posts.
The group’s innovative and interdisciplinary profile allows doctoral candidates in the field of statistics to acquire comprehensive knowledge of toxicology. This will empower them to develop and apply statistical methods systematically to questions in pharmacological and environmental toxicology. A special feature are the planned practical modules, which include laboratory weeks at the Leibniz institutes involved on the one hand and work experience with industrial partners on the other.
Statistical methods for answering toxicology questions
In terms of content, the doctoral researchers will develop statistical methods suitable for answering specific toxicological questions. In toxicology, innovative statistical methods are urgently required in order to make optimum use of the constantly growing flood of molecular data. One of the group’s specialties is that it uses complex, high-dimensional data.
This means, for example, that genetically defined groups in the population can be identified that react particularly strongly to air pollutants. Preventive measures can then be developed to protect them. When determining the minimum dose of a substance or drug required for it still to be effective, combinations of genetic markers are sought that identify such critical values more precisely. Researchers can explore the role of genetic modifications in diseases such as fatty liver with the help of integrative models that combine different molecular data.
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.