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€ 4.5 MILLION FOR PROJECT „BIOSTATISTICAL METHODS FOR HIGH-DIMENSIONAL DATA IN TOXICOLOGY“

German Research Foundation Funds New Research Training Group

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Building of the faculty of mathematics © Nikolas Golsch​/​TU Dort­mund
Math Tower at TU Dort­mund University: The group’s in­no­va­ti­ve and interdisciplinary profile allows doctoral candidates in the field of statistics to acquire comprehensive knowledge of toxicology.

The German Research Foundation (DFG) has decided on the establishment of Research Training Group (RTG) 2624 “Biostatistical Methods for High-Dimensional Data in Toxicology” at TU Dort­mund University. It will fund the group, whose spokesperson is Professor Jörg Rahnenführer from the uni­ver­si­ty’s Faculty of Statistics, from March next year for initially four years. The grant is worth € 4.5 million.

Within the RTG, statisticians from TU Dort­mund University and a colleague from Heinrich Heine University Düsseldorf will supervise doctoral students in cooperation with toxicologists from the Leibniz Research Center for Working Environment and Human Factors (IfADo) at TU Dort­mund University and the Leibniz Research Institute for Environmental Medicine (IUF) in Düsseldorf. The funding from the German Research Foundation will be used to finance one postdoctoral and ten doctoral posts.

The group’s in­no­va­ti­ve and interdisciplinary profile allows doctoral candidates in the field of statistics to acquire comprehensive knowledge of toxicology. This will empower them to develop and apply statistical methods systematically to questions in pharmacological and environmental toxicology. A special feature are the planned practical modules, which include laboratory weeks at the Leibniz institutes involved on the one hand and work experience with industrial partners on the other.

Statistical methods for answering toxicology questions

In terms of content, the doctoral researchers will develop statistical methods suitable for answering specific toxicological questions. In toxicology, in­no­va­ti­ve statistical methods are urgently required in order to make optimum use of the constantly growing flood of molecular data. One of the group’s specialties is that it uses complex, high-dimensional data.

This means, for example, that genetically defined groups in the population can be identified that react particularly strongly to air pollutants. Preventive measures can then be developed to protect them. When determining the minimum dose of a substance or drug required for it still to be effective, com­bi­na­tions of genetic markers are sought that identify such critical values more precisely. Re­searchers can explore the role of genetic mod­i­fi­ca­tions in diseases such as fatty liver with the help of integrative models that combine different molecular data.

 

Contact for further in­for­mation:

Professor Jörg Rahnenführer from the Faculty of Statistics at TU Dort­mund University is the RTG’s spokesperson.

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Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The facilities of TU Dort­mund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

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